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205. López-Magano, A.; Solans-Monfort, X.; Salaverri, N.; Marzo, L.*; Mas-Ballesté, R.*; Alemán, J*. Engineering photocatalytic porous organic materials for directing redox vs energy transfer processes. RRL Solar 2023. DOI: 10.1002/solr.202300768.


204. Valle-Amores, M. Á.; Feberero, C.; Martin-Somer, A.; Díaz-Tendero, S.; Smith, A. D.; Fraile, A.*; Alemán, J*. Intramolecular hydrogen bond activation for kinetic resolution of furanone derivatives by an organocatalyzed [3+2] asymmetric cycloaddition. Org. Chem. Front. 2023. DOI: 10.1039/D3QO01471A.

203. Mollari, L.; del Río-Rodríguez, R.; Fernández-Salas, J. A.*; Alemán, J.* Batch and flow electrochemical synthesis of allyl sulfones via sulfonation of allyl trifluoroborates: A robust, regioselective, and scalable approach. Green Chem. 2023. DOI: 10.1039/D3GC02408C.


202. Nova-Fernández, J.; Pascual-Coca, G.; Cabrera, S.*; Alemán, J.* Rapid and safe continuous-flow Simmons-Smith cyclopropanation using a Zn/Cu couple column. Adv. Synth. Catal. 2023. DOI: 10.1002/adsc.202300665.


201. Salaverri, N.; Alemán, J.*; Marzo, L.* Harnessing the power of the De Mayo reaction: unveiling a photochemical and photocatalytic masked [2+2] methodology for organic synthesis. Adv. Synth. Catal. 2023. DOI: 10.1002/adsc.202300647.

200. Boztepe, T.; Scioli-Montoto, S.; Gambaro, R. C.; Esperanza Ruiz, M.; Cabrera, S.; Alemán, J.; Islan, G. A.; Castro, G. R.; León, I. E*. Design, synthesis, characterization, and evaluation of the anti-tumoral activity of novel 8-oxyquinolinate-platinum(II)-loaded nanostructured lipid carriers targeted with riboflavin. Pharmaceutics 2023, 15 (3), 1021 accepted. DOI: 10.3390/pharmaceutics15031021.


199. López-Magano, A.; Daliran, S.; Oveisi, A. R.*; Mas-Ballesté, R.; Dhakshinamoorthy, A.; Alemán, J.*; Garcia, H.*; Luque, R*. Recent advances in the use of covalent organic frameworks as heterogeneous photocatalysts in organic synthesis. Adv. Mat. 2023, 2209475. DOI: 10.1002/adma.202209475


198. Humbrías-Martin, J.; Fernández Salas, J. A.; Alemán, J.* Procesos organocatalíticos de desimetrización enantioselectiva. Anales de Química 2022, 118, 198. 


197. Rodríguez, R.; Sicignano, M.; García, M. J.; Enríquez, R. G.; Cabrera, S.; Alemán, J.* Taming photocatalysis in flow: easy and speedy preparation of α-aminoamide derivatives. Green Chem. 2022, 24, 6613. DOI: 10.1039/D2GC02087D. Highlighted by H. Yamamoto and I. Ramakrishna in Synfacts 2022, 18 (11), 1272 (DOI: 10.1055/s-0041-1738734) and

196. López-Magano, A.; Salaverri, N.; Marzo, L.*; Mas-Ballesté, R.*; Alemán, J.* Synergistic combination of triazine and phenanthroline moieties in a covalent triazine framework tailored for heterogeneous photocatalytic metal-free C-Br and C-Cl activation. Appl. Catal. B-Environ. 2022, 317, 121791. DOI: 10.1016/j.apcatb.2022.121791.

195. Sciarretta, M.; Barawi, M.; Navío, C.; de la Peña O’ Shea, V.; Blanco, M.*; Alemán, J.* A graphene acid - TiO2 nanohybrid as multifunctional heterogeneous photocatalyst for the synthesis of 1,3,4-oxadiazoles. ACS Appl. Mater. Inter. 2022, 14, 34975. DOI: 10.1021/acsami.2c07880.


194. Río-Rodríguez, R.; Blanco, L.; Collado, A.; Fernández-Salas, J. A.*; Alemán, J.* Nickel-catalysed cross-electrophile coupling of benzyl bromides and sulfonium salts towards the synthesis of dihydrostilbenes. Chem. Eur. J. 2022, e202201644. DOI: 10.1002/chem.202201644.


193. Moya, A.*; Alemán, J.; Gomez-Herrero, J.; Mas-Ballesté, R.*; de Pablo, P.* Nanotribology and electrical properties of carbon nanotubes hybridized with covalent organic frameworks. Carbon 2022, 199, 80-86. DOI: 10.1016/j.carbon.2022.07.053.


192. González-Muñoz, D.; Alemán, J.*; Blanco, M.*; Cabrera, S.* Single walled carbon nanotubes with encapsulated Pt(II) photocatalyst for the oxidation of sulfides in water. J. Catal. 2022, 413, 274-283. DOI: 10.1016/j.jcat.2022.06.027.


191. Río-Rodríguez, R.; Westwood, M. T.; Sicignano, M.; Juhl, M.; Fernández-Salas, J. A.; Alemán, J.*; Smith, A. D.* Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions. Chem. Commun. 2022, 58, 7277. DOI: 10.1039/D2CC02432B.

190. Marzo, L.; Alemán, J. Chapter Title: Recent approaches in asymmetric non-covalent organo-photocatalysis. Book title: Photochemistry: Volume 50. Ed. Stefano Crespi and Stefano Protti. Royal Society of Chemistry, 2022.

189. Nowok, A.; Cieslik, W; Grelska, J.; Jurkiewicz, K.; Makieieva, N.; Kupka, T.; Alemán, J.; Musioł, R*; Pawlus, S. Simple rules for complex near-glass-transition phenomena in medium-sized Schiff bases. Int. J. Mol. Sci. 2022, 23, 5185. DOI: 10.3390/ijms23095185.


188. Daliran, S.; Reza Oveisi, A.*; Peng, Y.; López-Magano, A.; Khajeh, M.; Mas-Ballesté, R.; Alemán, J.*; Luque, R.*; Garcia, H.* Metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and porous-organic polymers (POPs)-catalyzed selective C-H bond activation and functionalization reactions. Chem. Soc. Rev. 2022, 51, 7810-7882. DOI: 10.1039/D1CS00976A.


187. del Río-Rodríguez, R.; Fragoso-Jarillo, L.; Garrido-Castro, A.F.; Maestro, M.C.; Fernández-Salas, J.A.*, Alemán, J.* General electrochemical Minisci alkylation of N-heteroarenes with alkyl halides. Chem. Sci. 2022, 13, 6512-6518. DOI: 10.1039/D2SC01799G. Highlighted in: Highlighted as back cover.


186. Salaverri, N.; Carli, B.; Gratal, P.; Marzo, L.*; Alemán, J.* Remote Giese radical addition by photocatalytic ring opening of activated cycloalkanols. Adv. Synth. Catal. 2022, 364, 1689. DOI: 10.1002/adsc.202200220.


185. Salaverri, N.; Carli, B; Díaz-Tendero, S.; Marzo, L.*; Alemán, J.* Enantioselective addition of remote alkyl radicals to double bonds by photocatalytic proton-coupled electron transfer (PCET) deconstruction of unstrained cycloalkanols. Org. Lett. 2022, 24, 3123. DOI: 10.1021/acs.orglett.2c00662Selected for cover issue: Volume 24, Issue 17. and most accessed articles in Organic Letters in May 2022.


184. Nova-Fernández, J.L.; García, M. J.; Mollari, L.; Pascual, G.; Cabrera, S.*; Alemán, J.* Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles. Chem. Commun. 2022, 58, 4611. DOI: 10.1039/D2CC01065H. Highlighted in Organic Process Research & Development:

183. Guerrero-Corella, A., Fraile, A.*; Alemán, J.* Intramolecular hydrogen-bond activation: Strategies, benefits, and influence in catalysis. ACS Org. Inorg. Au 2022, 2 (3), 197-204. DOI: 10.1021/acsorginorgau.1c00053. By invitation of the editor of the journal, Prof. Géraldine Masson.

182. Jiménez-Almarza, A.; López-Magano, A.; Mas-Ballesté, R.*; Alemán, J.* Tuning the activity−stability balance of photocatalytic organic materials for oxidative coupling reactions. ACS Appl. Mater. Inter. 2022, 14, 16258. DOI: 10.1021/acsami.2c01646.


181. Rodríguez, R.; Sicignano, M.; Alemán, J.* Fluorinated sulfinates as source of alkyl radicals in the photo‐enantiocontrolled β‐functionalization of enals. Angew. Chem. Int. Ed. 2022, e20211263. DOI: 10.1002/anie.202112632Most accessed articles in ACIE, in 2022. Most accessed articles in January 2022 in Angewandte Chemie. Highlighted in:


180. Valle-Amores, M. A.; Blanco, M.*; Agnoli, S.; Fraile, A.*; Alemán, J.* Oxidized multiwalled nanotubes as efficient carbocatalyst for the general synthesis of azines. J. Catal. 2022, 406, 174. DOI: 10.1016/j.jcat.2022.01.009.

179. Mollari, L.; Valle-Amores, M. A.; Martínez-Gualda, A. M.; Marzo, L.; Fraile, A.*; Alemán, J.* Asymmetric synthesis of cyclic β-amino carbonyl derivatives by a formal [3+2] photocycloaddition. Chem. Commun. 2022, 58, 1334. DOI: 10.1039/D1CC05867C. Highlighted in

178. González-Muñoz, D.; Gómez-Avilés, A.; Molina, C. B.; Bedia, J.; Belver, C.*; Alemán, J.*; Cabrera, S.* Anchoring of 10-phenylphenothiazine to mesoporous silica materials: A water compatible organic photocatalyst for the degradation of pollutants. J. Mater. Sci. Technol. 2022, 102, 134. DOI: 10.1016/j.jmst.2021.07.004.

177. Alemán, J.; Marzo, L.; Fernández-Salas, J. A.; Fraile, A. Chapter: Merging Organocatalysis with Light – new Opportunities for Asymmetric Synthesis, in Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities, 2 Volumes, Lukasz Albrecht (Editor), Anna Albrecht (Editor), Luca Dell'Amico (Editor), Wiley, 2022.


176. López-Magano, A.; Mas-Ballesté, R.*; Alemán, J.* Predesigned covalent organic frameworks as effective platforms for Pd(II) coordination enabling cross-coupling reactions under sustainable conditions. Adv. Sustain. Syst. 2021, 2100409. DOI: 10.1002/adsu.202100409. By invitation of the Editorial Office.


175. Nowok, A.*; Cieślik, W.; Dulskicd, M.; Jurkiewicz, K.; Grelsk, J.; Alemán, J.; Musioł, R.; Szeremeta, A.; Pawlus, S. Glass-forming Schiff bases: Peculiar self-organizing systems with bifurcated hydrogen bonds. J. Mol. Liq. 2021, 118052. DOI: 10.1016/j.molliq.2021.118052.

174. Sánchez-Fuente, M.; Jimenez-Almarza, A.; Alemán, J.*; Mas-Ballesté, R.* Solvent-free visible light photocatalytic oxidation processes mediated by transparent films of an imine-based organic polymer. Catalysts 2021, 11, 1426. DOI: 10.3390/catal11121426.

173. Blanco, M.*; Cembellín, S.*; Agnoli, S.; Alemán, J.* Ruthenium-p-cymene complex side-wall covalently bonded to carbon nanotubes as efficient hybrid transfer hydrogenation catalyst. ChemCatChem 2021, 13, 5156. DOI: 10.1002/cctc.202101442.

172. Rio-Rodríguez, R.; Laina-Martín, V.; Fernández-Salas, J.*; Alemán, J.* Enantioselective vinylogous Mukaiyama aldol reaction of a-ketoesters under bifunctional organocatalysis. Chem. Commun. 2021, 57, 11665. DOI: 10.1039/D1CC04263G.

171. López-Magano, A.; Ortín-Rubio, B.; Imaz, I.; Maspoch, D.; Alemán*, J.; Mas-Ballesté, R.* Photoredox heterobimetallic dual catalysis using engineered covalent organic frameworks. ACS Catal. 2021, 11, 12344. DOI: 10.1021/acscatal.1c03634. Highlighted in and Synfacts 2022, 18, 0065.

170. Laina-Martín, V.; Humbrías-Martín, J.; Mas-Ballesté, R.; Fernández-Salas, J. A.*; Alemán, J.* Enantioselective inverse-electron demand aza-Diels-Alder reaction: ipso,α-selectivity of silyl dienol ethers. ACS Catal. 2021, 11, 12133. DOI: 10.1021/acscatal.1c03390.

169. Kaur, K.; Humbrías-Martín, J.; Hoppmann, L.; Fernández-Salas, J. A.*; Daniliuc, J. C.; Alemán, J.*; García-Mancheño, O.* Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis. Chem. Commun. 2021, 57, 9244. DOI: 10.1039/D1CC03514B.

168. Jiménez-Almarza, A.; López-Magano, A.; Cano, R.; Ortín-Rubio, B.; Díaz-García, D.; Gomez-Ruiz, S.; Imaz, I.; Maspoch, D.; Mas-Balleste, R.*; Alemán, J.* Engineering covalent organic frameworks in the modulation of photocatalytic degradation of pollutants under visible light conditions. Mater. Today Chem. 2021, 22, 100548. DOI: 10.1016/j.mtchem.2021.100548. Highlighted in

167. Guerrero-Corella, A.; Valle-Amores, M. A.; Fraile, A*.; Alemán, J.* Enantioselective organocatalyzed aza-Michael addition reaction of 2-hydroxybenzophenone imines to nitroolefins under batch and flow conditions. Adv. Synth. Catal. 2021, 363, 3845. DOI: 10.1002/adsc.202100635.

166. Laina-Martín, V.; Fernández-Salas, J. A.*; Alemán, J.* Organocatalytic strategies for the development of the enantioselective inverse-electron-demand hetero-Diels Alder reaction. Chem. Eur. J. 2021, 27, 12509. DOI: 10.1002/chem.202101696Invitation and included in the special issue Non-Covalent Interactions-Wiley.

165. Alemán, J.; Mas-Ballesté, R. Photocatalytic oxidation reactions mediated by covalent organic frameworks and related extended organic materials. Front. Chem. 2021, 8, 708312. DOI: 10.3389/fchem.2021.708312By invitation of Prof. Xavier Xalas.

164. Aguilar-Galindo, F.; Rodríguez, R. I.; Alemán, J.; Mollari, L.; Alemán, J.*; Díaz-Tendero, S.* Visible-light radical–radical coupling vs. radical addition: disentangling a mechanistic knot. Catalysts 2021, 11, 922. DOI: 10.3390/catal11080922. By invitation of Prof. Cristina Trujillo.


163. Sicignano, M.; Rodríguez, R. I.; Alemán, J.* Recent visible light and metal free strategies in [2+2] and [4+2] photocycloadditions. Eur. J. Org. Chem. 2021, 3303. DOI: 10.1002/ejoc.202100518.

162. González-Muñoz, D.; Martín-Somer, A.; Strobl, K.; Cabrera, S.; De Pablo, P. J.; Díaz-Tendero, S.; Blanco, M.*; Alemán, J.* Enhancing visible-light photocatalysis via endohedral functionalization of single-walled carbon nanotubes with organic dyes. ACS Appl. Mater. Interfaces 2021, 13, 21, 24877. DOI: 10.1021/acsami.1c04679Highlighted as cover picture and in:

161. Cuéllar, E.; Diez-Varga, A.; Torroba, T.; Domingo-Legarda, P.; Alemán, J.; Cabrera, S.; Martín-Alvárez, J. M.; Miguel, D.; Villafañe, F.* Luminescent cis-bis(bipyridyl)ruthenium(II) complexes with 1,2-azolylamidino ligands: photophysical, electrochemical studies, and photocatalytic oxidation of thioethers. Inorg. Chem. 2021, 60, 7008. DOI: 10.1021/acs.inorgchem.0c03389.  


160. Martínez-Gualda, A. M.; Domingo-Lagarda, P.; Rigotti, T.; Díaz-Tendero, S.; Fraile, A.; Alemán, J.* Asymmetric [2+2] photocycloaddition via charge transfer complex for the synthesis of tricyclic chiral ethers. Chem. Commun. 2021, 57, 3046. DOI: 10.1039/D1CC00035GHiglighted in

159. Rodríguez, R.; Mollari, L.; Alemán, J.* A light driven enantioselective synthesis of pyrroline derivatives by radical/polar cascade reaction. Angew. Chem. Int. Ed. 2021, 23, 4555. DOI: 10.1002/anie.202013020. Highlighted in Synfacts, 2021, 17, 385.

158. Broto-Ribas, A.; Vignatti, C.; Jimenez-Almarza, A.; Luis-Barrera, J.; Dolatkhah, Z.; Gándara, F.; Imaz, I.*; Mas-Ballesté, R.*; Alemán, J.*; Maspoch, D.* Heterogeneous catalysts with programmable topologies generated by reticulation of organocatalysts into metal-organic frameworks: The case of squaramide. Nano Res. 2021, 14, 458–465. DOI: 10.1007/s12274-020-2779-8.


157. Cabrera-Alfonso, M. J.; Cembellín, S.; Halima-Salem, A.; Berton, M.; Marzo, L.; Miloudi, A.; Maestro, M. C.*; Alemán, J.* Metal-free visible light-promoted synthesis of isothiazoles: a catalytic approach for N−S bond formation from iminyl radicals under batch and flow conditions. Green Chem. 2020, 22, 6792. DOI: 10.1039/D0GC02618B.

156. Rios, Í. C.; Paulo-Corderio, J.; Parent, E. J. S.; Quintella, S. A.; Alemán, J. Cavalcante, C. L.; Luna, M.* Biodegradable base stock oils obtained from ricinoleic acid using C8 alcohols and process integration into a biodiesel industry. Biomass conversion and Biorefinery 2020, 11, 803. DOI: 10.1007/s13399-020-00942-4.

155. González-Muñoz, D.; Nova-Fernández, J. L.; Martinelli, A.; Pascual-Coca, G.; Cabrera, S.*; Alemán, J.* Visible light photocatalytic synthesis of tetrahydroquinolines under batch and flow conditions. Eur. J. Org. Chem. 2020, 5995. DOI: 10.1002/ejoc.202001018. Invitation to the YourJOC Talents Special Collection.

154. Salaverri, N.; Mas-Ballesté, R.; Marzo, L.*; Alemán, J.* Visible light mediated photocatalytic [2+2] cycloaddition/ring-opening rearomatization cascade of electron-deficient azaarenes and vinylarenes. Commun. Chem. 2020, 3, 132. DOI: 10.1038/s42004-020-00378-x.


153. Rigotti, T.; Alemán, J.* Visible light photocatalysis – from racemic to asymmetric activation strategies. Chem. Commun. 2020, 56, 11169-11190. DOI: 10.1039/D0CC03738A. Highlighted as feature article.


152. López-Magano, A.; Jiménez-Almarza, A.; Alemán, J.*; Mas-Ballesté, R.* Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) applied to photocatalytic organic transformations. Catalysis 2020, 10, 720. DOI: 10.3390/catal10070720. Highlighted as cover picture.


151. Domingo-Legarda, P.; Casado-Sánchez, A.; Marzo, Marzo, L.; Alemán, J.*; Cabrera, S.* Photocatalytic water soluble cationic platinum(II) complexes bearing quinolinate and phosphine ligands. Inorganic. Chem. 2020, 19, 13845. DOI: 10.1021/acs.inorgchem.0c01326.

150. Garrido-Castro, A.; Maestro, M. C.*; Alemán, J.* α-functionalization of imines via visible light photoredox catalysis. Catalysts 2020, 10, 562. DOI: 10.3390/catal10050562.


149. Ruiz del Árbol, N.; Sánchez-Sánchez, C.; Otero-Irurueta, G.; Martínez, J. I.; de Andrés, P. L.; Gómez-Herrero, A. C.; Merino, P.; Piantek, M.; Serrate, D.; Lacovig, P.; Lizzit, S.; Alemán, J.; Ellis, G.; López, M. F.; Martín-Gago, J. A.* On-surface driven formal Michael addition produces m-polyaniline oligomers on Pt(111). Angew. Chem. Int. Ed. 2020, 5, 23220. DOI: 10.1002/anie.202009863.


148. Moya, A.; Creus, J.; Romero, N.; Alemán, J.; Solans-Monfort, X.; Philippot, K.; García-Antón, J.; Sala, X.*; Mas-Ballesté, R.* Organocatalytic vs Ru-based electrochemical hydrogenation of nitrobenzene in competition with hydrogen evolution reaction. Dalton Trans. 2020, 49, 6446. DOI: 10.1039/D0DT01075H.


147. López-Magano, A.; Platero-Prats, A. E.; Cabrera, S.*; Mas-Ballesté, R.*; Alemán, J.* Incorporation of photocatalytic Pt(II) complexes into imine-based layered covalent organic frameworks (COFs) through monomer truncation strategy. Appl. Catal. B Environ. 2020, 272, 119027. DOI: 10.1016/j.apcatb.2020.119027. Highlighted in


146. Rodríguez, R.; Capaccio, V.; Borello, F.; Cano, R.; De Riccardis, F.; Bernardi, L.; Díaz-Tendero, S.; Della Sala, G.*; Alemán, J.* Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis. Org. Biomol. Chem. 2020, 18, 2914. DOI: 10.1039/D0OB00476F.

145. Garrido-Castro, A. F.; Gini, A.; Maestro, M. C.*; Alemán, J.* Unlocking the direct photocatalytic difluoromethylation of C=N bonds. Chem. Commun. 2020, 56, 3769. DOI: 10.1039/D0CC01353F.

144. Mallón, L.; Romero, N.; Jiménez, A.; Martín Morales, E.; Alemán, J.; Mas-Ballesté, R.; Bofill, R.; Philippot, K.; García-Antón, J.; Sala, X.* The role of catalyst-support interactions in oxygen evolution anodes based on Co(OH)2 nanoparticles and carbon microfibers. Catal. Sci. Technol. 2020, 10, 4513. DOI: 10.1039/D0CY00193GHighlighted as cover picture.


143. Rigotti, T.; Mas-Ballesté, R.; Alemán, J.* Enantioselective aminocatalytic [2+2] cycloaddition through visible light excitation. ACS Catal. 2020, 10, 5335. DOI: 10.1021/acscatal.0c01413Featured in Org. Chem. Highlights: Organocatalyzed carbocyclic ring construction.


142. Cruz-Delgado, B.; Rodríguez, R. I.; Rosado-Abón, A.; Sánchez-Obregón, R.; Yuste, F.*; Alemán, J.* Stereocontrolled addition of scrambling ortho-sulfinyl carbanions: easy access to homopropargylamines and alpha-allenylamines. Org. Lett. 2020, 22, 2431. DOI: 10.1021/acs.orglett.0c00625.


141. Rigotti, T.; Asenjo-Pascual, J.; Martín-Somer, A.; Milán Rois, P.; Cordani, M.; Díaz-Tendero, S.; Somoza, A.; Fraile, A.*; Alemán, J.* Boron dipyrromethene (BODIPY) as electron-withdrawing group in asymmetric copper-catalyzed [3+2] cycloadditions for the synthesis of pyrrolidine-based biological sensors. Adv. Synth. Cat. 2020, 362, 1345. DOI: 10.1002/adsc.201901465.


140. Capaccio, V.; Sicignano, M.; Rodríguez, R.; Della Sala, G.;* Alemán, J.* Asymmetric synthesis of alpha-trifluoromethylthio-beta-amino acids under phase transfer catalysis. Org. Lett. 2020, 22, 219. Article highlighted by Yamamoto in Synfacts 2020, 16, 0478. DOI: 10.1021/acs.orglett.9b04195.

139. Moya, A.; Pérez-Illana, M.; Hernando-Pérez, M.; San Martín, C.; Gómez-Herrero, J.; Alemán, J.;* Mas-Ballesté, R.;* de Pablo, P. J.* Multifunctional carbon nanotubes covalently coated with imine-based covalent organic frameworks: exploring structure-property relationships through nanomechanics. Nanoscale 2020, 12, 1128. DOI: 10.1039/C9NR07716B.


138. Laina-Martín, V.; Pérez, I.; Fernández-Salas, J. A.*; Alemán, J.* Nucleophilic halo-Michael addition under Lewis-base activation. Chem. Commun. 2019, 55, 12936. DOI: 10.1039/C9CC07068K.

137. Luis-Barrerra, J.; Cano, R.; Imani-Shakibaei, G.; Heras-Domingo, J.; Pérez-Carvajal, J.; Imaz, I.; Maspoch, D.; Solans-Monfort, X.; Alemán, J.;* Mas-Ballesté, R.* Switching acidic and basic catalysis through supramolecular functionalization in a porous 3D covalent imine-based material. Catal. Sci. Technol. 2019, 9, 6007. DOI: 10.1039/C9CY01527B.


136. Casado-Sánchez, A.; Domingo-Legarda, P.; Cabrera, S.*; Alemán, J.* Visible light photocatalytic asymmetric visible light photocatalytic asymmetric synthesis of pyrrolo[1,2-a]indoles via intermolecular [3+2] cycloaddition. Chem. Commun. 2019, 55, 11303. DOI: 10.1039/C9CC05838A.


135. Humbrías-Martín, J.; Pérez-Aguilar, M. C.; Mas-Ballesté, R.; Dentoni Litta, A.; Lattanzi, A.; Della Sala, G.; Fernández-Salas, J. A.*; Alemán, J.* Enantioselective conjugate azidation of alpha,beta-unsaturated ketones under bifunctional organocatalysis by direct activation of TMSN3. Adv. Synth. Cat. 2019, 361, 4790. DOI: 10.1002/adsc.201900831.


134. López-Calixto, C.; Cabrera, S.; Pérez-Ruiz, R.; Barawi, M.; Alemán, J.; de la Peña O'Shea, V. A.*; Liras, M.* Conjugated porous polymer based on BOPHY dyes as photocatalyst under visible light. Appl. Catal. B Environ. 2019, 258, 117933. DOI: 10.1016/j.apcatb.2019.117933.


133. Jiménez-Almarza, A.; López-Magano, A.; Marzo, L.; Cabrera, S.*; Mas-Ballesté, R.*; Alemán, J.* Imine‐based covalent organic frameworks as photocatalysts for metal free oxidation processes under visible light conditions. ChemCatChem 2019, 11, 4916. DOI: 10.1002/cctc.201901061This article was among the 10% most downloaded papers in 2019-2020 in ChemCatChem.


132. Garrido-Castro, A. F.; Salaverri, N.; Maestro, M. C.;* Alemán, J.* Intramolecular homolytic substitution enabled by photoredox catalysis – Sulfur, phosphorus and silicon heterocycle synthesis from aryl halides. Org. Lett. 2019, 21, 5295. DOI: 10.1021/acs.orglett.9b01911.


131. Gini, A.; Rigotti, T.; Pérez-Ruiz, R.; Uyugur, M.; Mas-Ballesté, R.; Corral, I.; Martínez-Fernández, I.; de la Peña O'Shea, V. A.; García Mancheño, O.;* Alemán, J.* Mesityl or imide acridinium photocatalysts: accessible versus inaccessible charge-transfer states in photoredox catalysis. ChemPhotoChem 2019, 3, 609. DOI: 10.1002/cptc.201900116.


130. Casado-Sánchez, A.; Uygur, M.; González-Muñoz, D.; Aguilar-Galindo, F.; Nova-Fernández, J. L.; Arranz-Plaza, J.; Díaz-Tendero, S.; Cabrera, S.*; García Mancheño, O.*; Alemán, J.* 8-Mercaptoquinoline as a ligand for enhancing the photocatalytic activity of Pt(II) coordination complexes: reactions and mechanistic insights. J. Org. Chem. 2019, 84, 6437. DOI: 10.1021/acs.joc.9b00520.


129. Martínez-Gualda, A. M.; Cano, R.; Marzo, L.; Pérez-Ruiz, R.; Luis-Barrera, J.; Mas-Ballesté, R.; Fraile, A.; de la Peña O'Shea, V. A.; Alemán, J.* Chromoselective access to Z- or E- allylated amines and heterocycles by a photocatalytic allylation reaction. Nature Commun. 2019, 10, 2634. DOI: 10.1038/s41467-019-10441-4. Highlighted in


128. González-Muñoz, D.; Casado-Sánchez, A.; del Hierro, I.; Gómez-Ruiz, S.*; Cabrera, S.*;  Alemán, J.* Size-selective mesoporous silica-based Pt(II) complex as efficient and reusable photocatalytic material. J. Catal. 2019, 373, 374. DOI: 10.1016/j.jcat.2019.04.015.


127. Guerrero-Corella, A.; Asenjo-Pascual, J.; Janardan Pawar, T.; Díaz-Tendero, S.; Martín-Sómer, A.; Villegas Gómez, C.; Belmonte-Vázquez, J. L.; Ramírez-Ornelas, D. E.; Peña-Cabrera, E.; Fraile, A.; Cruz-Cruz, D.*; Alemán, J.* BODIPY as electron withdrawing group for the activation of double bonds in asymmetric cycloaddition reactions. Chem. Sci. 2019, 10, 4346. DOI: 10.1039/C9SC00959K.


126. Aguilar-Galindo, F.; Tuñón, A. M.; Fraile, A.; Alemán, A.; Díaz-Tendero, S.* Role of intramolecular hydrogen bonds and electron withdrawing groups in the acidity of aldimines and ketimines: a density functional theory study. Theor. Chem. Acc. 2019, 138, 49. DOI: 10.1007/s00214-019-2451-0.

125. Ruiz, M. C.; Resasco, A.; Di Virgilio, A. L.; Ayala, M.; Cavaco, I.; Cabrera, S.; Alemán, J.; Esteban León, I.* In vitro and in vivo anticancer effects of two quinoline-platinum(II) complexes on human osteosarcoma model. Cancer Chemother. Pharmacol. 2019, 83, 681-692. DOI: 10.1007/s00280-019-03773-x.

124. Martín-Somer, A.*; Arpa, E. M.; Díaz-Tendero, S.*; Alemán, J.* Intramolecular hydrogen bond activation of aza‐methylene imines in hydrogen bond bifunctional catalysis – A density functional theory study. Eur. J. Org. Chem. 2019, 574. Invitation to a special issue in Organic Reaction Mechanisms by Prof. P. R. Schreiner and B. König. DOI: 10.1002/ejoc.201801208.



123. Rodríguez, R. I.; Ramírez, E.; Fernández-Salas, J. A.; Sánchez-Obregón, R.; Yuste, F.;* Alemán, J.* Asymmetric [2,3]-Wittig rearrangement: synthesis of homoallylic, allenylic and enynyl α-benzyl alcohols. Org. Lett. 2018, 20, 8047. DOI: 10.1021/acs.orglett.8b03659.

122. Laina-Martín, V.; del Río-Rodríguez, R.; Díaz-Tendero, S.; Fernández-Salas, J. A.*; Alemán, J.* Asymmetric synthesis of Rauhut−Currier type esters via Mukaiyama-Michael reaction to acylphosphonates under bifunctional catalysis. Chem. Commun. 2018, 54, 13941. Highlighted as inside cover.


121. Vignatti, C.; Luis-Barrera, J.; Guillerm, V.; Imaz, I.;* Mas-Ballesté, R.;* Alemán, J.;* Maspoch, D.* Squaramide-IRMOF-16 analogue for catalysis of solvent-free, epoxide ring-opening tandem and multicomponent reactions. ChemCatChem 2018, 10, 3995. Open access:


120. Gini, A.; Uygur, M.; Rigotti, T.; Alemán, J.*; García Mancheño, O.* Novel oxidative Ugi‐reaction for the synthesis of highly active visible light imide‐acridinium organophotocatalysts. Chem. Eur. J. 2018, 24, 12509. Highlighted by T. M. Swager in Synfacts 2018, 14, 1133. DOI: 10.1002/chem.201802830.

119. Rigotti, T.; Casado-Sánchez, A.; Cabrera, S.; Pérez-Ruiz, R.; Liras, M.; A. de la Peña O'Shea, V.; Alemán, J.* A bifunctional photo-aminocatalyst for the alkylation of aldehydes: design, analysis and mechanistic studies. ACS Catal. 2018, 8, 5928. Highlighted by B. List in Synfacts, 2018, 984.

118. Frías, M.; Cieślik, W.; Fraile, A.; Rosado-Abón, A.; Garrido-Castro, A. F.; Yuste, F.*; Alemán, J.*. Development and application of asymmetric organocatalytic Mukaiyama and vinylogous-Mukaiyama-type reactions. Chem. Eur. J. 2018, 24, 10906. Highlighted as Frontpieze.

117. Choubane, H.; Garrido-Castro, A. F.; Alvarado, C.; Guerrero-Corella, A.; Daaou, M.; Maestro, C.; Fraile, A.; Martín-Somer, A.; Diaz Tendero, S.; Alemán, J.* Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary. Chem. Commun. 2018, 54, 3399. DOI: 10.1039/C8CC01479E.

116. Guerrero-Corella, A.; Esteban, F.; Iniesta, M.; Martín-Somer, A.; Parra, M.; Díaz-Tendero, S.; Fraile, A.;* Alemán, J.* 2-Hydroxybenzophenone as a chemical auxiliary for the activation of ketiminoesters for highly enantioselective addition to nitroalkenes under bifunctional catalysis. Angew. Chem. Int. Ed. 2018, 57, 5928. DOI: 10.1002/anie.201800435.

115. Laina-Martín, V.; Humbrías-Martín, J.; Fernández-Salas, J. A.*; Alemán, J.* Asymmetric vinylogous Mukaiyama aldol reaction of isatins under bifunctional organocatalysis: synthesis of substituted 3-hydroxy-2-oxindoles. Chem. Commun. 2018, 54, 2781. DOI: 10.1039/C8CC00759D.

114. Garrido-Castro, A. F.; Maestro, M. C.;* Alemán, J.* Asymmetric induction in photocatalysis – Discovering a new side to light-driven chemistry. Tetrahedron Lett. 2018, 59, 1286. Digest Article, Invitation by Prof. M. Christmann. DOI: 10.1016/j.tetlet.2018.02.040.

113. González-del Moral, O.; Call, A.; Franco, F.; Moya, A.; Nieto-Rodríguez, J. A.; Frías, M.; Fierro, J. L. G.; Costas, M.; Lloret-Fillol, J.; Alemán, J.; Mas-Ballesté, R.* Bioinspired electro-organocatalytic material efficient for hydrogen production. Chem. Eur. J. 2018, 24, 3305. DOI: 10.1002/chem.201705655. Highlighted in Europa Press (click here). 


112. Rodríguez, R. I.; Ramírez, E.; Yuste, F.*; Sánchez-Obregón, R.; Alemán, J.* Asymmetric synthesis of secondary and tertiary propargylic alcohols by umpolung of acetylenic sulfones and ortho-sulfinyl carbanions. J. Org. Chem. 2018, 83, 1940. DOI: 10.1021/acs.joc.7b02887.

111. Frías, M.; Carrasco, A. C.; Fraile, A.; Alemán, J.* A general asymmetric formal synthesis of aza-Baylis-Hillman type products under bifunctional catalysis. Chem. Eur. J. 2018, 24, 3117. DOI: 10.1002/chem.201705218Highlighted as cover picture.

110. Esteban, F.; Cieślik, W.; Arpa, E. M.; Guerrero-Corella, A.; Díaz-Tendero, S.; Perles, J.; Fernández-Salas, J. A.; Fraile, A.;* Alemán, J.* Intramolecular hydrogen bond activation: thiourea-organocatalyzed enantioselective 1,3-dipolar cycloaddition of salicylaldehyde-derived azomethine ylides with nitroalkenes. ACS Catal. 2018, 8, 1884. DOI:  10.1021/acscatal.7b03553Most read articles in ACS Catalysis in February-March 2018.



109. Guerrero-Corella, A.; Martinez-Gualda, A. M.; Ahmadi, F.; Ming, E.; Fraile, A.;* Alemán, J.* Thiol-ene/oxidation tandem reaction under visible light photocatalysis: synthesis of alkyl sulfoxides. Chem. Commun. 2017, 53, 10463. DOI: 10.1039/C7CC05672AOne of the most downloaded ChemComm article of 2017 and as the most important papers published in ChemComm (check it here). 


108. Garrido-Castro, A. F.; Choubane, H.; Daaou, M.; Maestro, C.*; Alemán, J.* Asymmetric radical alkylation of N-sulfinimines under visible light photocatalytic conditions. Chem. Commun. 2017, 53, 7764. DOI: 10.1039/C7CC03724D.

107. Luis-Barrera, J.; Laina-Martín, V.; Rigotti, T.; Peccati, F.; Solans-Monfort, X.; Sodupe, M.; Mas-Ballesté, R.; Liras, M.; Alemán, J.* Visible light photocatalytic intramolecular cyclopropane ring expansion. Angew. Chem. Int. Ed. 2017, 56, 7826. DOI: 10.1002/anie.201703334Most accessed articles in Angew. Chem. Int. Ed. in June 2017.

106. Casado-Sánchez, A.; Martín-Santos, C.; Padrón, J. M.; Mas-Ballesté, R.; Navarro-Ranninger, C.; Cabrera, S.;* Alemán, J.* Effect of electronic and steric properties of 8-substituted quinolines in gold(III) complexes: synthesis, electrochemistry, stability, interactions and antiproliferative studies. J. Inorg. Biochem. 2017, 174. 111. DOI: 10.1016/j.jinorgbio.2017.06.004.

105. Esteban, F.; Boughani, L.; García Ruano, J. L.; Fraile, A.*; Alemán, J.* "Anti-Michael addition" of Grignard reagents to sulfonylacetylenes: synthesis of alkynes. Org. Biomol. Chem. 2017, 15, 3901. DOI: 10.1039/C7OB00783C.

104. Agudo-López, A.; Prieto-García, E.; Alemán, J.; Pérez, C.; Díaz-García, V.; Parrilla-Rubio, L.; Cabrera, S.; Navarro-Ranninger, C.; Cortés-Funes, H.; López-Martín, J. A.; Agulló Ortuño, M. T. Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-platin. Mol. Cancer 2017, 16:45. DOI: 10.1186/s12943-017-0618-7. DOI: 10.1186/s12943-017-0618-7.

​103. Mas-Ballesté, R.; González, O.; Alemán, J. Procedimiento electroquímico para la generación de hidrógeno. Patente nacional: P13874ES00.

102. Frías, M.; Mas-Ballesté, R.; Arias, S.; Alvarado, C.; Alemán, J.* Asymmetric synthesis of Rauhut-Currier type products by a regioselective Mukaiyama reaction under bifunctional catalysis. J. Am. Chem. Soc. 2017, 139, 672. DOI: 10.1021/jacs.6b07851. Highlighted in Synfacts 2017, 10, 978 by B. List in the websites:,, in the following chemistry portal: and in the radio:




101. Gini, A.; Bamberger, J.; Luis-Barrera, J.; Zurro, M.; Mas-Ballesté, R.; Alemán, J.* García Mancheño, O.* Synthesis of 3-benzazepines by metal-free oxidative C–H bond functionalization–ring expansion tandem reaction. Adv. Synth. Cat. 2016, 358, 4049. DOI: 10.1002/adsc.201600985.

100. Marzo, L.; Luis-Barrera, J.; Mas-Ballesté, R.; García Ruano, J. L.; Alemán, J.* Stereodivergent aminocatalytic synthesis of Z and E trisubstituted double bonds from alkynals. Chem. Eur. J. 2016, 46, 16467. DOI: 10.1002/chem.201604695. Highlighted as cover picture and as a VIP article.

99. Marcos, V.; Alemán, J.* Old tricks, new dogs: organocatalytic dienamine catalysis of α,β-unsaturated aldehydes. Chem. Soc. Rev. 2016, 45, 6812. DOI: 10.1039/C6CS00438E.

98. Valderas, C.; Marzo, L.; de la Torre, M. C.; García Ruano, J. L.; Alemán, J.*; Casarrubios, L. Sierra, M. A.* Mono- and bimetallic alkynyl metallocenes and half-sandwich complexes: a simple and versatile synthetic approach. Chem. Eur. J. 2016, 24, 15645. DOI: 10.1002/chem.201603462.

97. Arpa, E. M.; Frías, M.; Alvarado, C.; Alemán, J.;* Díaz-Tendero, S.* Weakly bounded intermediates as a previous step towards highly-enantioselective iminium type additions of beta-keto-sulfoxides and –sulfones. J. Mol. Catal. A: Chem. 2016, 423, 308. DOI: 10.1016/j.molcata.2016.03.013.

96. Casado, A.; Gómez, R.; Tato, F.; Soriano, F. J.; Cabrera, S.;* Alemán, J.* Pt(II) coordination complexes as visible light photocatalysts for the oxidation of sulfides in batch and flow. Chem. Commun. 2016, 52, 9137. DOI: 10.1039/C6CC02452A.

95. Izquierdo, C.; Esteban, F.; García Ruano, J. L.; Fraile, A.;* Alemán, J.* Asymmetric Synthesis of 1,2-Diamines bearing Tetrasubstituted Centers from Nonstabilized Azomethine Ylides and N-Sulfinylketimines under Brønsted Acid Catalysis. Org. Lett. 2016, 18, 92.

94. Martín Santos, C.; Michelucci, E.; Marzo, T.; Mesori, L.; Szumlas, P.; Bednarski, P. J.; Mas-Ballesté, R.; Navarro Ranninger, C.; Cabrera, S.;* Alemán, J.* Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies. J. Inorg. Biochem. 2015, 152, 339. Most Downloaded Journal of Inorganic Biochemistry Articles in 2016.


93. Luis-Barrera, J.; Mas-Ballesté, R.; Alemán, J.* One-Pot Asymmetric Synthesis of Cyclopropanes with Quaternary Centers Starting from Bromonitroalkenes under Aminocatalytic Conditions. ChemPlusChem 2015, 80, 1595. 

92. Fraile, F.; Alemán, J.* Inter- and Intra-molecular Dienamine Organocatalytic Strategies for the Synthesis of Tetrahydroisoquinolines and Tricyclic Derivatives via [3+2] and [4+2] Cycloadditions. Synlett 2015, 14, 1940. Invited account by Prof. K. Peter C. Vollhardt.

91. Stopka, T.; Marzo, L.; Zurro, M.; Janich, S.; Würthwein, E.-U.; Daniliuc, C. G.; Alemán, J.*; García Mancheño, O.* Oxidative C-H Bond Functionalization-Ring Expansion Reaction with TMSCHN2: A Novel Cu(I)-Catalyzed Approach to Dibenzoxe- and Dibenzoazepines. Angew. Chem. Int. Ed. 2015, 54, 5049.

90. Frías, M.; Padrón, J. M.; Alemán, J.* Dienamine and Friedel-Crafts One-Pot Synthesis, and Antitumor Evaluation of Diheteroarylalkanals. Chem. Eur. J. 2015, 21, 8237.

89. Pérez, I.; Yuste, F.; Sánchez-Obregón, R.; Toscano, R. A.; Alemán, J.; Marzo, L.; Martín Castro, A. M.; Alonso, I.; García Ruano, J. L.* Synthesis of Enantiopure 1,5-Enynes and 1,5-Diynes with Propargylic Quaternary Centers. Eur. J. Org. Chem. 2015, 3314.

88. Alemán, J.; Cabrera, S.; Alvarado, C. Multicomponent Reactions: Concepts and Applications for Design and Synthesis. Edited by Raquel Herrera and Eugenia Marquez. Chapter 7: Recent Advances in the Ugi Multicomponent Reaction. pages: 247-283. 2015. Ed. Wiley.

87. Marzo, L.; Pérez, I.; Yuste, F.; Alemán, J.*; García Ruano, J. L.* A Straightforward Alkynylation of Li and Mg Metalated Heterocycles with Sulfonylacetylenes. Chem. Commun. 2015, 51, 346.


86. Izquierdo, C.; Esteban , F.; Parra, A.; Alfaro, R.; Alemán, J.;* Fraile, A.;* García Ruano, J. L. Control of the Dual Reactivity (Iminium-Dienamine) of β-Arylmethyl α,β-Unsaturated Aldehydes in Organocatalytic 1,3-Dipolar Cycloadditions with N-Benzoyl C,N-Cyclic Azomethine Imines. J. Org. Chem. 2014, 79, 10417.

85. Fraile, A.; Parra, A.; Tortosa, M.; Alemán, J.* Alkynals, Alkynones, Propiolates and Electron-Deficient Alkynes in Organocatalysis. Tetrahedron 2014, 70, 9145 (Review about alkynes in organocatalysis by invitation of Prof. Matthias Christmann).


84. Martín-Santos, C.; Jarava-Barrera, C.; del Pozo, S.; Parra, A.; Díaz-Tendero, S.; Mas-Ballesté, R.; Cabrera, S.; Alemán, J.* A Highly Enantioselective Construction of Tricyclic Derivatives via Desymmetrization of Cyclohexadienones. Angew. Chem. Int. Ed.  2014, 53, 8184. Highlighted in Synfacts 2014, 10, 978 by B. List, L. Liu.


83. Pérez, C.; Díaz-García, C. V.; Agudo-López, A.; del Solar, V.; Cabrera, S.; Agulló-Ortuño, M. T.; Navarro-Ranninger, C.; Alemán, J.;* López-Martín, J. A.* Progress in the Discovery and in the in vitro Evaluation of trans-Sulfonamide Platinum Complexes: Cytotoxicity and Early Pharmacodynamics. Eur. J. Med. Chem. 2014. 76, 360.


82. Esteban, F.; Alfaro, R.; Yuste, F.; Parra, A.; García Ruano, J. L.*; Alemán, J.* [8+2] Formal Cycloaddition Reaction of Tropones with Azlactones under Brønsted Acid Catalysis and Synthesis of a-(2-Tropyl) a-Alkyl a-Aminoacids. Eur. J. Org. Chem. 2014, 1395.

81. Lithium Compounds in Organic Synthesis: From Fundamentals to Applications. Edited by Vito Capriati and Renzo Luisi. Chapter 8: ‘Sulfur-bearing Lithium Compounds in Modern Synthesis’, pages 225-270. J. L. García Ruano, A. Parra, J. Alemán, 2014. Ed. Willey.

80. García Ruano, J. L.; Alemán, J.*; Parra, A.; Marzo, L. Sulfonyl Acetylenes as Alkynylating Reagents under Radical or Anionic Conditions. Eur. J. Org. Chem. 2014, 1577.

79. Izquierdo, C.; Luis-Barrera, J.; Fraile, A.; Alemán, J.* 1,4-Michael additions of cyclic β-keto esters catalyzed by DNA in aqueous media. Catal. Commun. 2014, 44, 10.


78. del Solar, V.; Quinones-Lombrana, A.; Cabrera, S.; Padrón, J. M.; Rios-Luci, C.; Álvarez-Valdés, A.; Navarro-Ranninger, C.; Alemán, J.* Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies. J. Inorg. Biochem. 2013, 127, 128.​

77. Martín Santos, C.; Cabrera, S.*, Padrón, J.; López Solera, I.; Quiroga, A.; Medrano, M. A.; Navarro Ranninger, C.; Alemán, J.* Novel Clioquinol and PBT2 Platinum Complexes: Importance and Role of the Halogen Substitution. Dalton Trans. 2013, 42, 13343.

76. Alfaro, R.; Parra, A.; Alemán, J.; Tortosa, M.* New Methods in Organic Synthesis via Copper-Catalyzed Borylation Reactions: Stereoselective Synthesis of 1,4-Diols and Vinylboronates. Synlett 2013, 24, 804.

75. Marzo, L.; Alemán, J.;* García Ruano, J. L.* Arylsulfonylacetylenes as Alkynylating Reagents. Phosphorus, Sulfur and Silicon 2013, 188, 403.

74. Marzo, L.; Parra, A.; Frías, M.; Alemán, J. ;* García Ruano, J. L.* Synthesis of Alkyl-Ynol-Ethers by “Anti-Michael Addition” of Metal Alkoxides to b-Substituted Alkynylsulfones. Eur. J. Org. Chem. 2013, 4405.

73. Stereoselective Organocatalysis: From C-C to C-heteroatom bond formation, Edited by Ramón Rios. Chapter 12. C-O bond formation. J. Alemán, M. Tortosa 2013, pages: 433-463.


72. Jarava-Barrera, C.; Esteban, F.; Navarro-Ranninger, C.; Parra, A.; Alemán, J.* Asymmetric synthesis of trans-dihydroaryl furans in a Friedel-Crafts/substitution domino reaction under squaramide catalysis. Chem. Commun. 2013, 49, 2001. Highlighted as cover picture.


71. Alemán, J.;* Cabrera, S.* Applications of Asymmetric Organocatalysis in Medicinal Chemistry. Chem. Soc. Rev. 2013, 42, 774.

70. Reboredo, S.; Parra, A.; Alemán, J.* Trienamines: Their Key Role in Extended Organocatalysis. Asymm. Organocat. 2013, 24-31 (DOI: 10.2478/asorg-2013-0001).


69. Agudo-López, A.; Pérez, C.; Díaz-García, C. V.; del Solar, V.; Alemán, J.; Agullo-Ortuño, M. T.; Cortes-Funes, H.; Navarro-Ranninger, C. Mechanistic Differences between a new platinum(II) mono-sulfonoamide and cisplatin in melanoma cell lines, Proceedings Book, Eur. J. Cancer 2012, n48, Poster 186.

68. Alfaro, R.; Parra, A.; Alemán, J.; García Ruano, J. L.; Tortosa, M.* Copper (I)-Catalyzed Formal Methylboration of Alkynes: Synthesis of Tri- and Tetrasubstituted Vinylboronates. J. Am. Chem. Soc. 2012, 134, 15165.

67. Parra, A.; Reboredo, S.; Alemán, J.* Asymmetric Synthesis of Cyclobutanes by a Formal [2+2] Cycloaddition Controlled by Dienamine Catalysis. Angew. Chem. Int. Ed. 2012, 51, 9734.


66. Parra, A.; Alfaro, R.; Marzo, L.; Moreno-Carrasco, A.; García Ruano, J. L.; Alemán, J.* Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis. Chem. Commun. 2012, 48, 9759.


65. Alemán, J.*; Fraile, A.*; Marzo, M.; García Ruano, J. L.; Izquierdo, C.; Díaz-Tendero, S. Enantioselective Synthesis of 4-Isoxazolines by 1,3-Dipolar Cycloadditions of Nitrones to Alkynals Catalyzed by Fluorodiphenylmethylpyrrolidines. Adv. Synth. Cat. 2012, 9, 1665.

64. García Ruano, J. L.; Marzo, L.; Alvarado, C.; Marcos, V.; Alemán, J.* Highly Stereoselective Synthesis of Tertiary Propargylic Centers and Their Isomerization to Enantiomerically Enriched Allenes. Chem. Eur. J. 2012, 18, 9775.

63. Martín-Santos, C.; Jarava-Barrera, C.; Parra, A.; Esteban, F.; Navarro-Ranninger, C.; Alemán, J.* Modular Three-Component Organocatalytic Synthesis of 3,4-Disubstituted Pyrroles by a One-Pot Domino Reaction. ChemCatChem 2012, 4, 976. Article highlighted by chemview, see: and highlighted as hottest article in willey as open-access (

62. García Ruano, J. L.;* Alemán, J.;* Marzo, L.; Alvarado, C.; Tortosa, M.; Díaz-Tendero, S.; Fraile, A. Expanding the Scope of Arylsulfonylacetylenes as Alkynylating Reagents and Mechanistic Insights in the formation of Csp2-Csp and Csp3-Csp Bonds from Organolithiums. Chem. Eur. J. 2012, 18, 8414. VIP ARTICLE, Highlighted as cover picture, and also by other chemical journals see:

61. García Ruano, J. L.;* Alemán, J.;* Marzo, L.; Alvarado, C.; Tortosa, M.; Díaz-Tendero, S.; Fraile, A. Arylsulfonylacetylenes as Alkynylating Reagents of Csp2-H Bonds Activated with Lithium Bases. Angew. Chem. Int. Ed. 2012, 51, 2712. Highlighted in Synfacts 2012, 8, 660 by P. Knochel.

60. Parra, A.; Reboredo, S.; Martín Castro, A. M.; Alemán, J.* Metallic Organophosphates as Catalysts in Asymmetric Synthesis: A Return Journey. Org. Biomol. Chem. 2012, 10, 5001. Highlighted as cover picture.

59. García Ruano, J. L.*, Torrente, E.; Parra, A.; Alemán, J.;  Martín-Castro, A. M. Asymmetric Intramolecular Pauson-Khand Reaction Mediated by a Remote Sulfenyl or Sulfinyl Group. J. Org. Chem. 2012, 77, 6583.



58. Alemán, J.;* del Solar, V.; Martín-Santos, C.; Cubo, L.; Navarro Ranninger, C. Tandem Cyclization-Michael Reaction by Combination of Metal- and Organocatalysis. J. Org. Chem. 2011, 76, 7287.


57. Marcos, V.; Alemán, J.;* García Ruano, J. L.; Marini, F.; Marcello Tiecco, Asymmetric synthesis of α-alkyl α-selenocarbonyl compounds catalyzed by bifunctional organocatalysts. Org. Lett., 2011, 13, 3052.

56. Fustero, S.;* Sánchez-Roselló, M.; Claribel Báez, M.; Pozo, C.; García Ruano, J. L.;* Alemán, J.; Marzo, L.; Parra, A. Asymmetric Synthesis of Quaternary α-Amino Acid Derivatives and their Fluorinated Analogues. Amino Acids, 2011, 41, 559.


55. Alemán, J.;* Alvarado, C.; Marcos, V.; Núñez, A. García Ruano, J. L.* Synthesis of 4-Hydroxy-4H-Chromenes by Reaction of Salicylic Aldehydes with Alkynals Catalyzed by Silyl-Prolinol-Ethers. Synthesis, 2011, 1840.

54. Alemán, J.;* Solar, V.; Álvarez-Valdés, A.; Padrón, J. M.; Ríos-Lucí, C.; Navarro-Ranninger, C.* Novel N-Sulfonamide Platinum Complexes: Synthesis, Reactivity and Invitro Evaluation. MedChemCommun. 2011, 2, 789.

53. García Ruano, J. L.;* Alvarado, C.; Díaz-Tendero, S.; Alemán, J.* Complete Stereocontrol in Organocatalytic Additions of β-Ketosulfoxides to Conjugated Aldehydes. Chem. Eur. J. 2011, 17, 4030.


52. Alemán, J.*; Parra, A.; Jiang, H.  Jørgensen, K. A. Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis. Chem. Eur. J. 2011, 17, 6890. Highlighted as Front-pieze in Chemistry. Most accessed mini-review in chemistry during 2011-2012. It is among the top 20 most cited Minireviews in Chemistry—A European Journal of the past 20 years.

51. García Mancheño, O.*; Tangen, P.; Rohlmann, R.; Fröhlich, R.; Alemán, J.* Synthesis of Chiral Cyclic Nitrones by Asymmetric Addition of β-Ketosulfones to Nitroalkenes followed by Reductive Cyclization. Chem. Eur. J. 2011, 17, 984. Highlighted in Synfacts 2011, 218 by B. List.

50. Navarro Ranninger, C.; Álvarez-Valdés, A.; Quiroga, A. G.; Vadillo, A.; Alemán, J. Mailliet, P.; Bernard, B.  New all trans platinum (IV) complexes, their preparation and their use as antitumor agents. WO2012/004385 A1, Sanofi-Aventis.


49. Alemán, J.; Navarro-Ranninger, M. C.; del Solar, V. Complejos de Platino con Geometría trans que Comprenden un Ligando Sulfonamida con Actividad Antitumoral, España. PCT PATENT: 201030278, WO_2011_104409-A1.

48. García Ruano, J. L.;* Schöpping, C.; Alvarado, C.; Alemán, J.* Synthesis of Unfunctionalized Carbonated Fragments Containing two Vicinal Chiral Centers: Stereocontrolled Benzylation of Vinylsulfones Mediated by a Remote Sulfinyl Group. Chem. Eur. J. 2010, 16, 8968.

47. Alemán, J.*; Marcos, V.; Marzo, L.; García Ruano, J. L.* Influence of the Reaction Conditions on the Evolution of the Michael Adition of β-Keto Sulfones to α,β-Unsaturated Aldehydes. Eur. J. Org. Chem. 2010, 4482. Highlighted at

46. Alemán, J.*; del Solar, V.; Gómez, A.; Cubo, L.; Navarro-Ranninger, C.* New Reactions of Anticancer-Platinum Complexes and their Intriguing Behaviour under Various Experimental Conditions. Dalton Trans. 2010, 39, 10601.

45. Alemán, J.*; Núñez, A.; Marzo, L.; Marcos, V.; Alvarado, C.; García Ruano, J. L. Asymmetric Synthesis of 4-Amino[4H]Chromenes by Organocatalytic Oxa-Michael/Aza-Baylis-Hillman Tandem Reactions. Chem. Eur. J. 2010, 16, 9453 Highlighted in the ”3rd Euchem Congress Issue”.

44. Alemán, J.*; del Solar, V.; Navarro-Ranninger, C.* Anticancer Platinum Complexes as Non-Innocent Compounds for Catalysis in Aqueous Media. Chem. Commun. 2010, 454.

43. García Ruano, J. L.; Alemán, J.; Cid, M. B.; Parra, A. Preparation of N-p-Tolylsulfonyl-(E)-1-phenylethylideneimine from p-Tolyldisulfide. Organic Colective Volumen XI, 2010. Libro de procedimientos sintéticos.


42. García Ruano, J. L.*; Marcos, V.; Alemán, J.* Synthesis of Optically Pure Allenes with Central and Axial Chirality Mediated by a Remote Sulfinyl Group. Synthesis 2009, 3339. Highlighted as Feature article.

41. Alemán, J.*; Cabrera, S. Nuevos Horizontes en Aminocatálisis Asimétrica. An. Quím. 2009, 105, 189.

40. García Ruano, J. L.*; Duce, S.; Alemán, J.; López-Cantarero, J.; Remuiñán, M. J.; Cid, M. B.* The Role of the Sulfinyl Group in the Copper Catalyzed Benzyl Reactions from 2-p-Tolylsulfinylbenzylstannanes. J. Sulfur Chem. 2009, 30, 370.

39. García Ruano, J. L.*; Marcos, V.; Alemán, J.* The Organocatalytic Addition of Bis(arylsulfonyl)methane to α,β-Unsaturated Aldehydes and the Synthesis of Optically Enriched 3-Methyl-Alkanols. Chem. Commun. 2009, 4435. Highlighted in

38. García Ruano, J. L.*; Marcos, V.; Suanzes, J. A.; Marzo, L.; Alemán, J.* One-Pot Synthesis of Pentasubstituted Cyclohexanes by a Michael Addition Followed by a Tandem Inter-Intra Double Henry Reaction. Chem. Eur. J. 2009, 15, 6576.


37. García Ruano, J. L.*; Marcos, V.; Alemán, J.* Complete Regio‐ and Stereoselectivity Control in the Halohydroxylation of Non‐activated Allenes Mediated by a Remote Sulfinyl Group. Angew. Chem. Int. Ed. 2009, 48, 3155.


36. Fustero, S.*; del Pozo, C.; Catalán, S.; Alemán J.; Parra, A.; Marcos, V. García Ruano, J. L.* A New Strategy for the Synthesis of Optically Pure β-Fluoroalkyl β-Amino Acid Derivatives. Org. Lett. 2009, 11, 641.


35. García Ruano, J. L.*; Alemán, J.;  Parra, A.; Alcudia, A.; Maya, C.; Synthesis and Stereoselective Halogenolysis of Optically Pure Benzylstannanes. J. Org. Chem. 2009, 74, 2145.


34. García Ruano, J. L.*; Parra, A.; Alemán, J.; Yuste, F.; Mastranzo, V. M. Monoalkylation of Primary Amines and N-Sulfinamides. Chem. Commun. 2009, 404. Highlighted as hot articule, in Synfacts and, y también en el portal de la revista de Química Orgánica: 26October.shtm).


33. Alemán, J.; Milelli, A.; Cabrera, S.; Reyes, E.; Jørgensen, K. A.* Asymmetric 1,4-Addition of Oxazolones to Nitroalkenes by Bifunctional Cinchona Alkaloid Thioureas Organocatalyst: Synthesis of α,α-Disubstituted α-Amino Acids. Chem. Eur. J. 2008, 14, 10958.

32. García Ruano, J. L.;* Alemán, J.; Catalán, S.; Marcos, V.; Monteagudo, S.; Parra, A.; del Pozo, C.; Fustero, S.* Anionic–Anionic Asymmetric Tandem Reactions: One-Pot Synthesis of Optically Pure Fluorinated Indolines from 2-p-Tolylsulfinyl Alkylbenzenes. Angew. Chem. Int. Ed. 2008, 47, 7941.


31. García Ruano, J. L.;* Marcos, V.; Alemán, J. Configurational Control of Benzyl Carbanion–Copper Complexes by Sulfinyl Groups: Synthesis of Optically Pure Allenes with Central and Axial Chirality. Angew. Chem. Int. Ed. 2008, 47, 6836. Highlighted in Synfacts by M. Lautens, J. Panteleev, Synfacts 2008, 1172 and y methodology/sn2-prime/page/2/


30. Cabrera, S.; Reyes, E.; Alemán, J.; Milelli, A.; Kobbelgaard, S.; Jørgensen, K. A.* Organocatalytic Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids and Derivatives. J. Am. Chem. Soc. 2008, 130, 12031. Highlighted in Synfacts by B. List, F. Lay, Synfacts 2008, 1220).


29. García Ruano, J. L.;* Parra, A.; Alemán, J. Efficient Synthesis of Disulfides by Air Oxidation of Thiols under Sonication. Green Chem. 2008, 10, 706.


28. Alemán, J.; Jacobsen, C. B.; Frisch, K.; Jørgensen, K. A.* Organocatalytic Asymmetric Vinylogous Addition to Quinones – Formation of Optically Active α-Aryl Ketones. Chem. Commun. 2008, 632.


27. García Ruano, J. L.; Alemán J.; M. Cid, M. B.; Fernández-Ibáñez, M. A.; Maestro, M. C.; Martín, R.; Martín Castro, A. M. Capítulo 3: “Asymmetric Transformation Mediated by Sulfinyl Groups" en el libro “Organosulfur Chemistry in Asymmetric Synthesis”. Wiley-VCH. Wiley & Sons. STM Books Wiley-VCH Verlag GmbH & Co. KGaA Boschstr. 12, 69469 Weinheim, Germany. Ed. John Wiley & Sons, 2008. Pág 55-158.

26. Cabrera, S.; Alemán, J.; Bolze, P.; Bertelsen, S.; Jørgensen, K. A.* An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita-Baylis-Hillman Reaction. Angew. Chem. Int. Ed. 2008, 47, 121. Highlighted in Synfacts 2008, 206.


25. Alemán, J.; Reyes, E.; Richter, B.; Overgaard, J.; Jørgensen, K. A.* Organocatalytic Asymmetric ”anti-Michael” Reaction of b-Ketoesters. Chem. Commun. 2007, 3921.

26. Cabrera, S.; Alemán, J.; Bolze, P.; Bertelsen, S.; Jørgensen, K. A.* An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita-Baylis-Hillman Reaction. Angew. Chem. Int. Ed. 2008, 47, 121. Highlighted in Synfacts 2008, 206.

24. Alemán, J.; Cabrera, S.; Maerten, E.; Overgaard, J.; Jørgensen, K. A.* Asymmetric Organocatalytic α-Arylation of Aldehydes. Angew. Chem. Int. Ed. 2007, 46, 5520. Highlighted as cover picture, Angew. Chem. Int. Ed. 46/29. Highlighted in Synfacts 2007, 874. Methodology scale up in: Org. Synth. 2014, 91, 175-184. 

23. Alemán, J.; Richter, B.; Jørgensen, K. A.* Organocatalytic Highly Enantioselective α-Arylation of β-Ketoesters. Angew. Chem. Int. Ed. 2007, 46, 5515. Highlighted as cover picture, Angew. Chem. Int. Ed. 46/29.

22. García Ruano, J. L.;* Alemán, J.; Alonso, I.; Parra, A.; Marcos, V.; Aguirre, J. π,π-Stacking versus Steric Effects in Stereoselectivity Control: Highly Diastereoselective Synthesis of syn-1,2-Diarylpropylamines. Chem. Eur. J. 2007, 13, 6179.

21. Poulsen, T.; Benardi, L.; Alemán, J.; Overgaard, J.; Jørgensen, K. A.* Organocatalytic Asymmetric Direct α-Alkynylation of Cyclic β-Ketoesters. J. Am. Chem. Soc. 2007, 129, 441.

20. García Ruano, J. L.;* Alemán, J.; Parra, A.; Cid, M. B. Preparation of N-p-Tolylsulfonyl-(E)-1-phenylethylideneimine. Org. Synth. 2007, 84, 129.


19. García Ruano, J. L.;* Martín-Castro, A.; Cid, M. B.; Alemán J. (S, Se,Te)-Cyclic-dialkyl sulfoxides. 39.13.4 Product Subclass 4: Cyclic Dialkyl Sulfoxides and Derivatives. Science of Synthesis (Houben–Weyl), 39. Pág. 757-810. Thieme Chemistry. 2007.​

18. García Ruano, J. L.;* Martín-Castro, A.; Cid, M. B.; Alemán J. (S, Se,Te)-Acyclic dialkyl sulfoxides. 39.4. Product Class 4: Acyclic Dialkyl Sulfoxides and Derivatives. Science of Synthesis (Houben–Weyl), 39. Pág. 245-390. Thieme Chemistry. 2007.


17. García Ruano, J. L.*; López-Cantarero, J.; de Haro, T.; Alemán, J.; Cid, M. B. Preparation of α-Amino Ketones, β-Amino Hydroxylamines Using Asymmetric Aza-Henry Reactions of N-p-Tolylsulfinylimines with Nitroethane. Tetrahedron 2006, 62, 12197.

16. García Ruano, J. L.;* Alemán, J.; García-Paredes, C. Oxidative Addition of Pd(0) to Ar-SO2R Bonds: Heck Type Reactions of Sulfones. Org. Lett. 2006, 8, 2683.

15. García Ruano, J. L.;* Alemán, J. 2-Methylpropane Sulfinyl Chloride. Contribution for the Encyclopedia of Reagent for Organic Synthesis [EROS]. Ed. John Wiley & Sons, 2006. DOI: 10.1002/047084289X.rn00706.

14. García Ruano, J. L.;* Alemán, J.; Cid, M. B. Quick Access to Optically Pure 2-(1-Hydroxybenzyl)piperidine and Pyrrolidine. Synthesis 2006, 687.




13. García Ruano, J. L.;* Alemán, J.; Fajardo, C.; Parra, A. A New General Method for the Preparation of N-Sulfonyloxaziridines. Org. Lett. 2005, 7, 5493.


12. García Ruano, J. L.;* Topp, M.; López-Cantarero, J.; Alemán, J.; Remuiñán, M. J.; Cid, M. B. Asymmetric Aza-Henry Reactions from N-p-Tolylsulfinylimines. Org. Lett. 2005, 7, 4407.


11. García Ruano, J. L.;* Alemán, J.; Parra, A. Highly Stereoselective Benzylation of N-Sulfinylketimines. J. Am. Chem. Soc. 2005, 127, 13048.

10. García Ruano, J. L.*; García Paredes, C.; Alemán, J. Approaches to the Stereocontrolled Synthesis of Anthracyclinones: Preparation of Optically Pure Bicyclic Intermediates for the Regioselective Construction of the Tetracyclic Skeleton. Arkivok 2005, 9, 253.


9. García Ruano, J. L.; Alemán, J.; Cid, M. B.; Parra, A. A General Method for the Preparation of N-Sulfonyl Aldimines and Ketimines. Org. Lett. 2005, 7, 179.



8. García Ruano, J. L; Alemán, J.*; Aranda, M. T.; Arévalo, M.; Padwa, A. Highly Stereoselective Vinylogous Pummerer Rearrangement. Phosphorus, Sulfur and Silicon 2005, 180, 1497.

7. García Ruano, J. L.; Alemán, J.*; Parra, A. Highly Stereoselective Reaction of γ-Sulfinyl Carbanions with Achiral Imines. Phosphorus, Sulfur and Silicon 2005, 180, 1209.

6. García Ruano, J. L.*; Alemán, J.; Aranda, M. T; Arévalo, M. J.; Padwa, A.* Highly Stereoselective Vinylogous Pummerer Reaction Mediate by Me3SiX. Org. Lett. 2005, 7, 19.


5. García Ruano, J. L.*; Alemán, J.; Aranda, M. T; Fernández-Ibáñez, M. A.; Rodríguez-Fernández, M.; Maestro, M. C.* Synthesis of Chiral ortho-(p-Tolylsulfinyl)benzyl Ketones. Tetrahedron 2004, 60, 10067.

4. García Ruano, J. L.;* Alemán, J.; Padwa, A.* A novel asymmetric vinylogous Tin-Pummerer rearrangement. Org. Lett. 2004, 6, 1757.

3. García Ruano, J. L.;* Alemán, J.; Prado, M.; Fernández, I. Stereoselective addition of α–sulfinyl carbanions to N-p-tolylsulfinylketimines: synthesis of optically pure 1,2,2’-trialkyl-2-aminoethanols. J. Org. Chem. 2004, 69, 4454.


2. García Ruano, J. L.;* Alemán, J. Stereocontrolled Reactions Mediated by a Remote Sulfoxide Group: Synthesis of Optically Pure anti-β-Amino Alcohols. Org. Lett. 2003, 5, 4513.

​1. García Ruano, J. L.;* Alemán, J.; Soriano, F. A. Facile synthesis of optically pure 1,2-diaryl (and 1-alkyl-2-aryl)ethyl and propylamines. Org. Lett. 2003, 5, 677. DOI: 10.1021/ol027464h.

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